Linked Life Data

4056045

Source:http://linkedlifedata.com/resource/pubmed/id/4056045

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-11-27
pubmed:abstractText
It is thought that cysts in polycystic kidneys originate from nephron segments and function in a manner similar to the segment or origin. The indirect evidence for this derives from studies of microanatomy and cyst fluid composition. Cysts with low Na+ have been classified as distal, whereas cysts with high Na+ have been classified as proximal. In order to directly determine the transport characteristics of cyst epithelium, cysts from a human polycystic kidney were studied in vitro using Ussing chamber techniques. Composition of cyst fluid was determined in parallel with these studies. Cysts with low Na+ (gradient cysts) demonstrate characteristics consistent with distal nephron origin including elevated potential difference (PD), short-circuit current (Isc), and low conductance. PD and Isc of gradient cysts were amiloride sensitive. Nongradient cysts, however, require additional characterization. At least two types of nongradient cysts were identified, one with characteristics consistent with proximal nephron origin and another apparently without function. These studies are the first direct evidence for active transport of cysts from human polycystic kidney and provide strong evidence to support the concept that cysts function in the same manner as the nephron segment of origin.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-168783, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-5824740, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-6248906, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-6269436, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-6336912, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-6742129, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-7039345, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-713285, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-7401457, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-7463949, http://linkedlifedata.com/resource/pubmed/commentcorrection/4056045-915936
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1688-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
In vitro function of cyst epithelium from human polycystic kidney.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't