Linked Life Data

4055264

Source:http://linkedlifedata.com/resource/pubmed/id/4055264

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1985-12-19
pubmed:abstractText
The in vitro degradation of rabbit articular cartilage explants was evaluated with and without the addition of retinoic acid under various experimental conditions. Retinoic acid at nontoxic concentrations ranging from 1 X 10(-7) to 1 X 10(-5) M significantly increased cartilage degradation. The addition of phenanthroline or cycloheximide, but not pepstatin, significantly inhibited spontaneous and retinoic-acid-stimulated cartilage degradation at pH 7. When the pH was reduced to 5, only pepstatin inhibited spontaneous and retinoic-acid-stimulated cartilage degradation. No chondroitin sulphate release was observed when the temperature was reduced to 4 degrees C. The different inhibitory profiles observed at pH 7 and pH 5 suggest that cartilage degradation at pH 7 is associated with the presence and synthesis of a neutral metalloproteinase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-0868
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
397-404
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Comparison of spontaneous and retinoic acid stimulated rabbit articular cartilage degradation in vitro.
pubmed:publicationType
Journal Article, In Vitro