Linked Life Data

4054242

Source:http://linkedlifedata.com/resource/pubmed/id/4054242

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-12-18
pubmed:abstractText
Nonphagocytic, nonadherent mononuclear cells from canine peripheral blood (PBMC) were shown to suppress colony formation in agar of autologous and allogeneic bone marrow granulocyte-macrophage progenitor cells (CFU-GM). Suppression required previous cell-to-cell contact in liquid culture between PBMC and bone marrow cells (BMC) and was time- and dose-dependent and resistant to x-irradiation with 20 Gy. Small BMC were less susceptible than large BMC, whereas day-7 and day-14 CFU-GM were equally suppressed. Cryo-preservation of BMC did not enhance CFU-GM inhibition. Spontaneous inactivation during liquid culture of CFU-GM or accessory cells by PBMC is the likely effector mechanism. Possible recognition structures are different from dog leukocyte antigens A and B. Canine PBMC or subpopulations thereof might participate in the regulation of normal hemopoiesis and in the rejection of hemopoietic stem cell grafts by natural killer cell-like mechanisms as has been suggested for human and murine natural killer cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0301-472X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1033-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Canine blood mononuclear cells mediate contact-dependent impairment of granulocyte-macrophage colony formation by bone marrow cells.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't