Linked Life Data

4052390

Source:http://linkedlifedata.com/resource/pubmed/id/4052390

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1985-12-5
pubmed:abstractText
The homologous series of optically active short-chain phosphatidylethanolamines (PE) from dibutyryl-PE to dioctanoyl-PE was synthesized. In addition, two monomeric short-chain phospholipid analogues that are not degraded by phospholipase A2 (1,2-bis[(butylcarbamyl)oxy]-sn-glycero-3-phosphocholine and the corresponding ethanolamine derivative) were synthesized. In contrast to the short-chain phosphatidylcholines (PC), short-chain PE's have defined solubilities in water. No break below the solubility limit was found in surface tension plots, suggesting that these compounds exist as monomers in aqueous solution. Only when a significant fraction of the molecules is negatively charged can they form micelles by themselves. Cobra venom phospholipase A2 hydrolyzes monomeric short-chain PE's at about the same rate as short-chain PC's but hydrolyzes long-chain PC's much more rapidly than long-chain PE's. The hydrolysis of short-chain PE's is found to be activated by phosphocholine-containing compounds only in the presence of an interface; in its absence phosphocholine-containing compounds can act as competitive inhibitors. Possible explanations for this phenomenon are considered.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0006-2960
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4201-8
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Short-chain phosphatidylethanolamines: physical properties and susceptibility of the monomers to phospholipase A2 action.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.