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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1985-11-6
|
| pubmed:abstractText |
The electrophysiologic effects of indecainide, a new class IC antiarrhythmic agent, were assessed in 10 patients with left ventricular dysfunction and inducible sustained ventricular tachycardia. Indecainide was administered intravenously in a dose of 60 to 90 mg/kg at a rate of 12.5 to 15 micrograms/kg/min. Indecainide had no effect on sinus node function or atrial and ventricular effective refractory periods. The AH (106 +/- 13 vs 130 +/- 24 msec, p less than 0.002) and HV (57 +/- 7 vs 73 +/- 19 msec, p less than 0.001) intervals were significantly increased. The QRS duration increased (102 +/- 9 vs 120 +/- 13 msec, p less than 0.001); however, the JT duration did not change. Induction of ventricular tachycardia was prevented in 1 of 10 patients. In the remaining nine patients, the ventricular tachycardia cycle length was significantly prolonged (248 +/- 47 vs 320 +/- 71 msec, p less than 0.001). Indecainide significantly depressed intracardiac conduction at several sites.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0002-8703
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
784-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:4050649-Adult,
pubmed-meshheading:4050649-Aged,
pubmed-meshheading:4050649-Anti-Arrhythmia Agents,
pubmed-meshheading:4050649-Atrioventricular Node,
pubmed-meshheading:4050649-Cardiac Pacing, Artificial,
pubmed-meshheading:4050649-Electrocardiography,
pubmed-meshheading:4050649-Electrophysiology,
pubmed-meshheading:4050649-Female,
pubmed-meshheading:4050649-Fluorenes,
pubmed-meshheading:4050649-Heart Ventricles,
pubmed-meshheading:4050649-Hemodynamics,
pubmed-meshheading:4050649-Humans,
pubmed-meshheading:4050649-Infusions, Parenteral,
pubmed-meshheading:4050649-Male,
pubmed-meshheading:4050649-Middle Aged,
pubmed-meshheading:4050649-Recurrence,
pubmed-meshheading:4050649-Sinoatrial Node,
pubmed-meshheading:4050649-Tachycardia
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
The clinical electrophysiology of intravenous indecainide.
|
| pubmed:publicationType |
Journal Article
|