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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
|
pubmed:dateCreated |
1985-11-13
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pubmed:abstractText |
[1-14C]Butyl glycidyl ether administered orally to male rats and rabbits (20 mg/kg) is rapidly absorbed and metabolized. Most of the administered compound, 87% (rat) and 78% (rabbit), is eliminated in the 0-24 urine. Major metabolites in the rat include 3-butoxy-2-hydroxypropionic acid (9%), 3-butoxy-2-acetylaminopropionic acid (23%) and butoxyacetic acid (10%). 3-Butoxy-2-hydroxypropionic acid (35%) and butoxyacetic acid (5%) are also major metabolites in the rabbit. Biotransformations of the glycidyl ether and their likely biochemical mechanisms are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0049-8254
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
579-89
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:4049898-Animals,
pubmed-meshheading:4049898-Biotransformation,
pubmed-meshheading:4049898-Chemical Phenomena,
pubmed-meshheading:4049898-Chemistry,
pubmed-meshheading:4049898-Epoxy Compounds,
pubmed-meshheading:4049898-Ethers, Cyclic,
pubmed-meshheading:4049898-Male,
pubmed-meshheading:4049898-Mass Spectrometry,
pubmed-meshheading:4049898-Rabbits,
pubmed-meshheading:4049898-Rats,
pubmed-meshheading:4049898-Rats, Inbred Strains
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pubmed:year |
1985
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pubmed:articleTitle |
The metabolism of n-butyl glycidyl ether in the rat and rabbit.
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pubmed:publicationType |
Journal Article
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