Linked Life Data

4048774

Source:http://linkedlifedata.com/resource/pubmed/id/4048774

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-11-8
pubmed:abstractText
Primary Chinese hamster embryo cultures exposed chronically to 1-methylguanine or 7-methylguanine, modified purines derived from nucleic acid turnover, exhibit a number of properties characteristic of transformed cell lines. One of the earliest effects observed following exposure of cells to the methylated purines is an alteration in cell surface properties as measured by the interaction of the cells with the lectin concanavalin A. Within sixteen hours following inclusion of the compounds in the culture medium, the cells exhibit an increase in concanavalin A mediated hemadsorption. The increase in hemadsorption is accompanied by an alteration in distribution of receptors within the cell population as measured by flow microfluorometry using fluorescin conjugated concanavalin A, and by a decrease in the total number of receptors as measured by binding of radiolabelled concanavalin A. Possible mechanisms for these alterations and their significance for growth control are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1010-4283
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Alterations in cell surface properties induced by modified purines.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.