Linked Life Data

4048163

Source:http://linkedlifedata.com/resource/pubmed/id/4048163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-11-20
pubmed:abstractText
Local anesthetics have been shown to have an effect on neurotransmission. In this study we examined the effect of a local anesthetic, etidocaine, on the uptake, efflux, and release of norepinephrine (NE) from central nerve terminals. The studies were performed on synaptosomes and vesicles prepared from rat brains. Etidocaine 10(-4) M inhibited synaptosomal accumulation of [3H]NE and did not significantly effect vesicular accumulation of this neurotransmitter. This concentration of etidocaine also augmented efflux of norepinephrine from synaptosomal preparations. This augmented efflux was primarily due to an increase in the deaminated metabolite 3,4-dihydroxyphenylglycol (DOPEG). The presence of etidocaine did not significantly alter the release of NE from synaptosomes superfused with high potassium (40 mM), a calcium-dependent exocytotic release process. These results indicate that in the central nervous system, as previously demonstrated in the peripheral nervous system, high concentrations of etidocaine alter vesicular storage of NE, resulting in more NE leaking into the cytoplasm where it is metabolized to an inactive metabolite.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
180
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
264-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The effect of etidocaine on spontaneous and evoked release of norepinephrine from rat brain synaptosomes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.