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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1985-11-6
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pubmed:abstractText |
Using two different models, the effect on the blood-brain barrier of intracarotid injections of sodium/meglumine ioxaglate at similar iodine concentrations (280 mgI/ml) was investigated. In both models the degree of blood-brain barrier damage was assessed visually using Evans' Blue stain. Quantitative assessment of blood-brain barrier disruption was made by contrast enhancement as measured by CT of the dog brain, and by 99mTc-pertechnetate uptake by the brain in the rabbit model. No Evans' Blue staining was observed in any study using the canine/CT model. Slight staining was observed in two studies with ioxaglate using the rabbit/pertechnetate model. Statistical analysis of results from the canine/CT model did not detect any damage to the blood-brain barrier with either ioxaglate or saline control studies (P greater than 0.1). However, in the rabbit/pertechnetate model a slight increase in disruption of the blood-brain barrier was observed with ioxaglate compared with control studies, but this was only significant at the 0.1 level. The results suggest that the rabbit/pertechnetate model is a more sensitive measure of blood-brain barrier disruption than the canine/CT model. This study also demonstrates that blood-brain barrier disruption following intracarotid injection of ioxaglate is minimal.
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pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0028-3940
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
27
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
342-5
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:4047391-Animals,
pubmed-meshheading:4047391-Blood-Brain Barrier,
pubmed-meshheading:4047391-Carotid Arteries,
pubmed-meshheading:4047391-Contrast Media,
pubmed-meshheading:4047391-Dogs,
pubmed-meshheading:4047391-Female,
pubmed-meshheading:4047391-Injections, Intra-Arterial,
pubmed-meshheading:4047391-Iodobenzoates,
pubmed-meshheading:4047391-Ioxaglic Acid,
pubmed-meshheading:4047391-Male,
pubmed-meshheading:4047391-Rabbits,
pubmed-meshheading:4047391-Triiodobenzoic Acids
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pubmed:year |
1985
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pubmed:articleTitle |
Effects of intracarotid ioxaglate on the normal blood-brain barrier. A comparison of two animal models.
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pubmed:publicationType |
Journal Article,
Comparative Study
|