Linked Life Data

4047335

Source:http://linkedlifedata.com/resource/pubmed/id/4047335

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-11-1
pubmed:abstractText
Intraperitoneal administration of 2-cyclooctyl-2-hydroxyethyl-amine (CONH; 25-75 mg/kg) produced dose-related reductions in the epinephrine (EPI) concentrations in both the hypothalamic and brainstem regions, but not in the adrenal glands. The reductions in the hypothalamic and brainstem EPI concentrations in rats anesthetized with pentobarbital sodium were accompanied by parallel increases in blood glucose. These data suggest that CONH induces its hyperglycemia action at least in part by altering central EPI biosynthesis. This hyperglycemic was antagonized by spinal transection or adrenalectomy, but not by vagotomy. This indicates that CONH increases the adrenal-sympathetic efferent activity and leads to hyperglycemia in rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0028-3835
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Decreasing brain epinephrine levels with 2-cyclooctyl-2-hydroxyethylamine induces hyperglycemia in rats.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't