Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1985-11-7
|
| pubmed:abstractText |
The synthesis and preliminary pharmacological evaluation of the optical antipodes of the title compound (+/-)-1 (CV 205-502) is presented. The dopaminomimetic activity is shown to reside entirely in the (-) enantiomer. Crystallographic analysis has proven that the absolute configuration of the active (-) enantiomer corresponds to that of its ergoline analogue 3 (CQ 32-084) and of apomorphine (5).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1540-2
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:4045929-Aminoquinolines,
pubmed-meshheading:4045929-Animals,
pubmed-meshheading:4045929-Apomorphine,
pubmed-meshheading:4045929-Crystallography,
pubmed-meshheading:4045929-Male,
pubmed-meshheading:4045929-Molecular Conformation,
pubmed-meshheading:4045929-Rats,
pubmed-meshheading:4045929-Receptors, Dopamine,
pubmed-meshheading:4045929-Stereoisomerism,
pubmed-meshheading:4045929-Structure-Activity Relationship
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.
|
| pubmed:publicationType |
Journal Article
|