Linked Life Data

404368

Source:http://linkedlifedata.com/resource/pubmed/id/404368

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1977-6-30
pubmed:abstractText
The capacity of mycobacteria to enhance the nonspecific resistance of mice to bacterial infections was related to the presence of cord factor. After enzymatic digestion and delipidation, cell walls lost their immunopotentiating activity, which was restored, however, by the addition of cord factor. Cord factor administered alone protected mice effectively against virulent organisms unrelated to mycobacteria. Moreover, although this glycolipid is usually injected as a solution in mineral oil, our data show its effectiveness when administered in metabolizable peanut oil or even as a suspension in water. Since cord factor is a chemically well-defined molecule (6,6'-trehalose dimycolate), this glycolipid should constitute a new and useful tool for the investigation of nonspecific immunity to infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
771-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Enhancement of nonspecific immunity to bacterial infection by cord factor (6,6'-trehalose dimycolate).
pubmed:publicationType
Journal Article