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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1985-11-8
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pubmed:abstractText |
It has been established in male Wistar rats that the uptake capacity of the reticuloendothelial system (RES) increased 5-fold 1, 3 and 7 days after prodigiozan administration (50 micrograms). This was linked with the increased hepatocyte resistance to CCl4 which reached a maximum 7 and 21 days after RES stimulation. As compared with non-stimulated animals, the resistance increase looked as a 2.7- and 3.5-fold shrinkage of the necrotic zones in the central parts of liver lobules 24 h after CCl4 poisoning and less increment of alanine aminotransferase activity in blood serum (3.5- and 3.3-fold decrease, respectively). The increased resistance continued being recordable throughout a month after prodigiozan treatment.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0014-8318
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:4043370-Alanine Transaminase,
pubmed-meshheading:4043370-Animals,
pubmed-meshheading:4043370-Carbon Tetrachloride,
pubmed-meshheading:4043370-Drug Resistance,
pubmed-meshheading:4043370-Kupffer Cells,
pubmed-meshheading:4043370-Male,
pubmed-meshheading:4043370-Necrosis,
pubmed-meshheading:4043370-Polysaccharides, Bacterial,
pubmed-meshheading:4043370-Prodigiozan,
pubmed-meshheading:4043370-Rats,
pubmed-meshheading:4043370-Rats, Inbred Strains,
pubmed-meshheading:4043370-Stimulation, Chemical,
pubmed-meshheading:4043370-Time Factors
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pubmed:articleTitle |
[Increased hepatocyte resistance to CC14 following the stimulation of rats with a bacterial polysaccharide].
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pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|