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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-11-5
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pubmed:abstractText |
To establish dosage recommendations in patients with end-stage renal disease undergoing chronic haemodialysis, nifedipine kinetics were studied between and during haemodialysis sessions. In eight patients, during the interdialytic period, peak plasma concentrations of nifedipine (29-332 ng/ml) were reached 0.5-1.0 h after administration of a single 10 mg oral dose. Elimination half-life and oral plasma clearance were respectively 2.6 +/- 0.5 h and 1 176 +/- 412 ml/min. Nifedipine plasma protein binding was decreased in uraemic patients (88.8 +/- 0.3% vs 94.4 +/- 0.1%) but not affected by haemodialysis. Removal by haemodialysis was low: the dialyser extraction ratio and the dialysis clearance were respectively 2.3 +/- 0.8% and 2.8 +/- 0.9 ml/min.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-407044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-4211693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-4406644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-4939603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-6529535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-6734025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-6863580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-7437254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-762212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-797494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4041333-938543
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4041333-Adult,
pubmed-meshheading:4041333-Aged,
pubmed-meshheading:4041333-Blood Proteins,
pubmed-meshheading:4041333-Female,
pubmed-meshheading:4041333-Humans,
pubmed-meshheading:4041333-Kinetics,
pubmed-meshheading:4041333-Male,
pubmed-meshheading:4041333-Mathematics,
pubmed-meshheading:4041333-Middle Aged,
pubmed-meshheading:4041333-Models, Biological,
pubmed-meshheading:4041333-Nifedipine,
pubmed-meshheading:4041333-Protein Binding,
pubmed-meshheading:4041333-Renal Dialysis
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pubmed:year |
1985
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pubmed:articleTitle |
Haemodialysis does not affect the pharmacokinetics of nifedipine.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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