Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1A
pubmed:dateCreated
1985-5-23
pubmed:abstractText
The anticholinergic substance (8r)-6 beta, 7 beta-epoxy-8-ethyl-3 alpha-[(-)-tropoyloxyl]-1 alpha H, 5 alpha H-tropanium bromide (oxitropium bromide, Ba 253 BR, Ventilat) is a competitive antagonist of acetylcholine. In vitro, it is many times as effective as atropine. In vivo, oxitropium bromide, following i.v. administration, is also more effective than atropine. Due to its quaternary structure, a central anticholinergic effect cannot be demonstrated. Furthermore, poor enteral resorption is to be expected. Locally administered, as an aqueous aerosol, the effect of the substance is distinctly greater than that of atropine, both in potency and duration of action. This is also true when administered by metered-dose inhaler compared with ipratropium bromide. As, following aerosol administration, the margin between major effect and the most sensitive side-effect is in the ratio 1 : 100, side-effects are unlikely even with marked inhalational overdosage. Oxitropium bromide can be described, therefore, as a preparation free of side-effects which represents in prophylactic use in many cases of obstructive airway disease, an alternative to beta-mimetics and xanthine derivatives.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:4039183-Acetylcholine, pubmed-meshheading:4039183-Animals, pubmed-meshheading:4039183-Blood Pressure, pubmed-meshheading:4039183-Bronchial Spasm, pubmed-meshheading:4039183-Dogs, pubmed-meshheading:4039183-Electrocardiography, pubmed-meshheading:4039183-Female, pubmed-meshheading:4039183-Gastric Mucosa, pubmed-meshheading:4039183-Guinea Pigs, pubmed-meshheading:4039183-Heart Rate, pubmed-meshheading:4039183-Male, pubmed-meshheading:4039183-Mice, pubmed-meshheading:4039183-Muscle, Smooth, pubmed-meshheading:4039183-Muscle Contraction, pubmed-meshheading:4039183-Mydriatics, pubmed-meshheading:4039183-Oxotremorine, pubmed-meshheading:4039183-Parasympatholytics, pubmed-meshheading:4039183-Rats, pubmed-meshheading:4039183-Salivation, pubmed-meshheading:4039183-Scopolamine Derivatives, pubmed-meshheading:4039183-Species Specificity
pubmed:year
1985
pubmed:articleTitle
[Pharmacology of the bronchospasmolytic oxitropium bromide].
pubmed:publicationType
Journal Article, In Vitro, English Abstract