Linked Life Data

4038319

Source:http://linkedlifedata.com/resource/pubmed/id/4038319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-10-7
pubmed:abstractText
Modification of the polypeptide anthopleurin-A with a carbodiimide and glycine ethyl ester leads to the addition of nearly two Gly to AP-A. Limited amino acid sequence analysis shows that modification occurs principally at Asp-7 and Asp-9. The modified derivative shows no cardiac stimulatory activity. 1H nuclear magnetic resonance and circular dichroism spectra of the derivative show that its conformation is significantly altered. Thus, the Asp residues are essential for the cardiac stimulatory activity of AP-A, as well as for maintaining its native conformation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0158-5231
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-76
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Role of aspartate residues in the cardiac stimulatory activity of anthopleurin-A.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't