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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1977-5-20
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pubmed:abstractText |
Hypothalamic-pituitary function was assessed in 20 adult subjects who were treated with cerebral irradiation for brain tumours during childhood between 8 and 32 years earlier. Nine patients showed impaired growth hormone (GH) responses to hypoglycaemia, of whom, 7 are below the third centile for standing height. All GH deficient subjects received more than 2950 rads to the hypothalamic-pituitary axis with a maximum dose of approximately 5000 rads being used in one case. Three subjects have an elevated basal serum thyroid stimulating hormone (TSH) level and 2 of these show an exaggerated TSH response to thyrotrophin releasing hormone (TRH) but no patient was clinically or biochemically hypothyroid. The rest of hypothalamic-pituitary function was essentially normal. This study shows that multiple pituitary hormone deficiencies do no develop with time when the radiation dose is below a critical level. Thus it appears that there is a gradation of radiation damage to the hypothalamic-pituitary axis which is dependent primarily on the dose received rather than the time interval after radiotherapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Pituitary Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Thyroxine,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0001-5598
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
673-80
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:403723-Adolescent,
pubmed-meshheading:403723-Adult,
pubmed-meshheading:403723-Blood Glucose,
pubmed-meshheading:403723-Body Height,
pubmed-meshheading:403723-Brain Neoplasms,
pubmed-meshheading:403723-Child,
pubmed-meshheading:403723-Dose-Response Relationship, Radiation,
pubmed-meshheading:403723-Female,
pubmed-meshheading:403723-Follicle Stimulating Hormone,
pubmed-meshheading:403723-Growth Hormone,
pubmed-meshheading:403723-Humans,
pubmed-meshheading:403723-Hydrocortisone,
pubmed-meshheading:403723-Hypothalamus,
pubmed-meshheading:403723-Luteinizing Hormone,
pubmed-meshheading:403723-Male,
pubmed-meshheading:403723-Menarche,
pubmed-meshheading:403723-Pituitary Diseases,
pubmed-meshheading:403723-Pituitary Gland,
pubmed-meshheading:403723-Pituitary Gland, Anterior,
pubmed-meshheading:403723-Pituitary Hormones,
pubmed-meshheading:403723-Prolactin,
pubmed-meshheading:403723-Radiation Injuries,
pubmed-meshheading:403723-Testosterone,
pubmed-meshheading:403723-Thyrotropin,
pubmed-meshheading:403723-Thyrotropin-Releasing Hormone,
pubmed-meshheading:403723-Thyroxine,
pubmed-meshheading:403723-Time Factors,
pubmed-meshheading:403723-Triiodothyronine
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pubmed:year |
1977
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pubmed:articleTitle |
Endocrine morbidity in adults treated with cerebral irradiation for brain tumours during childhood.
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pubmed:publicationType |
Journal Article
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