Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-10-23
|
| pubmed:abstractText |
Altered accumulation and subcellular disposition of testicular Cd were examined as possible explanations for the resistance to Cd-induced testicular damage observed in certain inbred strains of mice. Mouse strains susceptible (129/J) or resistant (A/J) to Cd-induced testicular necrosis were injected iv with 10 or 45 mumol CdCl2/kg, respectively. This dosing regimen compensated for decreased Cd accumulation by A/J testes and established similar concentrations of Cd in testes of both strains (approximately 4 nmol Cd/g tissue). Twenty-four hours later, 129/J testes showed marked interstitial hemorrhage and seminiferous tubule necrosis, while A/J testes showed no microscopic evidence of damage. Two hours postinjection, no histopathologic changes were detected in testes of either strain; however, A/J testes had 15% more Cd associated with the cystosol than 129/J testes, and three times more Cd bound to a 14,500 MW cytosolic protein which had gel filtration and ion-exchange chromatography properties in common with metallothionein (MT). Therefore, resistance of A/J testes to Cd does not appear to be determined solely by decreased Cd accumulation, but is associated with increased binding of testicular Cd to a MT-like protein. However, this increase is not accompanied by a proportional increase in the total Cd-binding capacity of the MT-like protein in A/J testes compared to 129/J testes.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0041-008X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
511-23
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:4035692-Animals,
pubmed-meshheading:4035692-Cadmium,
pubmed-meshheading:4035692-Chromatography, DEAE-Cellulose,
pubmed-meshheading:4035692-Chromatography, Gel,
pubmed-meshheading:4035692-Chromatography, Ion Exchange,
pubmed-meshheading:4035692-Copper,
pubmed-meshheading:4035692-Drug Resistance,
pubmed-meshheading:4035692-Freezing,
pubmed-meshheading:4035692-Male,
pubmed-meshheading:4035692-Metallothionein,
pubmed-meshheading:4035692-Mice,
pubmed-meshheading:4035692-Mice, Inbred Strains,
pubmed-meshheading:4035692-Molecular Weight,
pubmed-meshheading:4035692-Rats,
pubmed-meshheading:4035692-Spectrophotometry, Atomic,
pubmed-meshheading:4035692-Subcellular Fractions,
pubmed-meshheading:4035692-Testis,
pubmed-meshheading:4035692-Zinc
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Resistance to cadmium-induced necrosis in testes of inbred mice: possible role of a metallothionein-like cadmium-binding protein.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|