Linked Life Data

4035291

Source:http://linkedlifedata.com/resource/pubmed/id/4035291

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-10-8
pubmed:abstractText
Principal cells of mouse gallbladder epithelium were subjected to quantitative electron microscopic investigation either after superstimulation with pilocarpine for 12 days or 6 weeks after vagotomy at different levels. Cholinergic superstimulation caused a slight hypertrophy of the principal cells, whereas different types of vagotomy induced hypotrophic changes. In the superstimulated animals there was decreased sensitivity to single-dose stimulation with pilocarpine. In contrast, a supersensitivity was recorded in mice subjected to vagotomy. It is concluded that the parasympathetic nervous system is of importance for the regulation of glycoprotein secretion from mouse gallbladder principal cells. The demonstrated vagotomy-induced super-sensitivity may be responsible for an increased glycoprotein release, which in turn may be involved in the formation of gallstones occurring after truncal vagotomy in man.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0036-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
727-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Glycoprotein secretion from mouse gallbladder principal cells after chronic variation in parasympathetic activity. A morphometric study after vagotomy and cholinergic superstimulation.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't