| pubmed-article:4034395 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0039476 | lld:lifeskim |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0599882 | lld:lifeskim |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0599533 | lld:lifeskim |
| pubmed-article:4034395 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:4034395 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:4034395 | pubmed:dateCreated | 1985-10-8 | lld:pubmed |
| pubmed-article:4034395 | pubmed:abstractText | Analogs of alternating purine-pyrimidine DNA polymers such as poly(dA-dT)-poly(dA-dT) can be made with phosphorothioate groups in the DNA backbone. A phosphorothioate diester at the 5'-purine-pyrimidine-3' step causes a significant lowering of the polymer's melting temperature compared to a phosphorothioate diester at the 5'-pyrimidine-purine-3' step. This may occur because sulfur substitution increases anionic charge density in the DNA minor groove and 5'-purine-pyrimidine-3' steps narrow the minor groove. The ability to modulate charge density in the DNA backbone via sulfur substitution should prove useful in studies of sequence-dependent conformational changes in DNA. | lld:pubmed |
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| pubmed-article:4034395 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4034395 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4034395 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4034395 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:4034395 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:4034395 | pubmed:author | pubmed-author:TaylorD ADA | lld:pubmed |
| pubmed-article:4034395 | pubmed:author | pubmed-author:SuggsJ WJW | lld:pubmed |
| pubmed-article:4034395 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4034395 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:4034395 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:4034395 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4034395 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4034395 | pubmed:pagination | 5707-16 | lld:pubmed |
| pubmed-article:4034395 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4034395 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4034395 | pubmed:articleTitle | Evidence for sequence-specific conformational changes in DNA from the melting temperatures of DNA phosphorothioate derivatives. | lld:pubmed |
| pubmed-article:4034395 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4034395 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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