Linked Life Data

4028801

Source:http://linkedlifedata.com/resource/pubmed/id/4028801

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1985-10-18
pubmed:abstractText
The Chediak-Higashi syndrome (CHS) is a genetic disorder of man, cats, and four other animal species. Enlarged cytoplasmic granules, including lysosomes and melanosomes, characterize the syndrome. Cats affected with CHS lack funduscopically visible tapeta. In normal cats, the tapetum is the light reflecting cellular layer located in the choroid. The tapetal cells contain bundles of parallel cytoplasmic rods. In this study, eyes from CHS and control cats were examined by light microscopy and transmission electron microscopy. The CHS kittens up to 14 days of age had tapeta which appeared similar to those of the controls. By 28 days of age some of the CHS tapetal rods had degenerated. Degeneration of the tapetal rods progressed rapidly and by 56 days of age there was a dramatic difference in the ultrastructural appearance of the tapetal cells. All the rods had degenerated and the contents of the tapetal cells were disorganized. The tapetal layer gradually thinned over a period of several months until the layer was absent or nearly so in CHS cats over one year of age. This study demonstrated that there is a previously overlooked degenerative component of the Chediak-Higashi syndrome.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0271-3683
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
767-73
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Tapetal degeneration in cats with Chediak-Higashi syndrome.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.