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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1985-9-4
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|
pubmed:abstractText |
A technique is described that allows simultaneous and quantitative assay of the action of agonists and antagonists at histamine H1- and H2-receptors in anesthetized guinea pigs. The principle of the technique is based on H1-receptor bronchoconstriction and H2-receptor tachycardia. Studies have been made to assay antagonists at either receptor and provide simultaneous evidence of selectivity or to assay combined antagonists such as Smith Kline & French 93319. Studies with histamine receptor agonists provide evidence of the potency and selectivity of these compounds relative to histamine.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0160-5402
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
309-15
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|
pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:4021497-Animals,
pubmed-meshheading:4021497-Betahistine,
pubmed-meshheading:4021497-Bronchi,
pubmed-meshheading:4021497-Cimetidine,
pubmed-meshheading:4021497-Female,
pubmed-meshheading:4021497-Guinea Pigs,
pubmed-meshheading:4021497-Heart Rate,
pubmed-meshheading:4021497-Histamine,
pubmed-meshheading:4021497-Male,
pubmed-meshheading:4021497-Pyrilamine,
pubmed-meshheading:4021497-Receptors, Histamine,
pubmed-meshheading:4021497-Receptors, Histamine H1,
pubmed-meshheading:4021497-Receptors, Histamine H2
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pubmed:year |
1985
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|
pubmed:articleTitle |
A simple technique to simultaneously assess activity at histamine H1- and H2-receptors in vivo.
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pubmed:publicationType |
Journal Article
|
