Linked Life Data

4021479

Source:http://linkedlifedata.com/resource/pubmed/id/4021479

Statements in which the resource exists.
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pubmed-article:4021479pubmed:abstractTextThe oxygen dependence of oestrogen (oestrone and 17 beta-oestradiol) formation from androstenedione and testosterone was studied in term human placental microsomes and in cultured human choriocarcinoma cells (BeWo line). Incubations were performed under various steady-state oxygen concentrations and the production of oestrone and 17 beta-oestradiol quantitated by specific radioimmunoassays. The aromatization of C19-steroids by both placental microsomes and choriocarcinoma cells was shown to be oxygen dependent over a wide range of O2 concentrations. The results indicate that placental oxygenation may be a critical factor in determining oestrogen production in vivo. Therefore, impaired oestrogen biosynthesis due to hypoxia could be an important factor in a variety of physiological and pathological conditions.lld:pubmed
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pubmed-article:4021479pubmed:articleTitleOxygen dependence of oestrogen production by human placental microsomes and cultured choriocarcinoma cells.lld:pubmed
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pubmed-article:4021479pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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