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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1985-9-13
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pubmed:abstractText |
The oxygen dependence of oestrogen (oestrone and 17 beta-oestradiol) formation from androstenedione and testosterone was studied in term human placental microsomes and in cultured human choriocarcinoma cells (BeWo line). Incubations were performed under various steady-state oxygen concentrations and the production of oestrone and 17 beta-oestradiol quantitated by specific radioimmunoassays. The aromatization of C19-steroids by both placental microsomes and choriocarcinoma cells was shown to be oxygen dependent over a wide range of O2 concentrations. The results indicate that placental oxygenation may be a critical factor in determining oestrogen production in vivo. Therefore, impaired oestrogen biosynthesis due to hypoxia could be an important factor in a variety of physiological and pathological conditions.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-4731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
753-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:4021479-Androstenedione,
pubmed-meshheading:4021479-Aromatase,
pubmed-meshheading:4021479-Cell Line,
pubmed-meshheading:4021479-Choriocarcinoma,
pubmed-meshheading:4021479-Estradiol,
pubmed-meshheading:4021479-Estrogens,
pubmed-meshheading:4021479-Estrone,
pubmed-meshheading:4021479-Female,
pubmed-meshheading:4021479-Humans,
pubmed-meshheading:4021479-Microsomes,
pubmed-meshheading:4021479-NADP,
pubmed-meshheading:4021479-Oxidation-Reduction,
pubmed-meshheading:4021479-Oxidoreductases,
pubmed-meshheading:4021479-Oxygen,
pubmed-meshheading:4021479-Placenta,
pubmed-meshheading:4021479-Pregnancy,
pubmed-meshheading:4021479-Testosterone,
pubmed-meshheading:4021479-Uterine Neoplasms
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pubmed:year |
1985
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pubmed:articleTitle |
Oxygen dependence of oestrogen production by human placental microsomes and cultured choriocarcinoma cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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