Linked Life Data

4020209

Source:http://linkedlifedata.com/resource/pubmed/id/4020209

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-8-29
pubmed:abstractText
Antibody-dependent cellular cytotoxicity (ADCC) and total and alternative pathway complement (C) activity were found to be normal in lepromatous leprosy (LL) patients in the presence of elevated circulating immune complexes (CIC) measured by the 125I-Clq binding assay. Heat inactivation (56 degrees C, 30 min) uncovered the ADCC inhibitory activity of LL sera. The effect of C was exerted both by interfering with the blocking action of CIC and by recovering ADCC activity of CIC-blocked effector cells. Heat inactivation allowed the expression of total and alternative C pathway fixing ability of the LL sera. Thus, immune complexes potentially able to block Fc receptor-dependent functions or capable of fixing C can be detected in LL sera. We postulate that compensatory mechanisms such as those described in vitro may contribute to maintain intact ADCC activity in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0148-916X
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
218-24
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Inhibition of antibody-dependent, cell-mediated cytotoxicity by serum from lepromatous leprosy patients.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't