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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1985-9-16
|
| pubmed:abstractText |
Superfusion with 5 micrograms/ml amiodarone for 3-4 h induced use-dependent Vmax block in dog Purkinje and guinea pig ventricular muscle fibers. The recovery from block was exponential with tau of 289 +/- 30 ms in Purkinje (n = 7) and 282 +/- 47 ms in muscle (n = 6) fibers. The onset of frequency-dependent Vmax block was rapid, i.e. reached steady state after 4.2 +/- 0.5 beats (n = 5). The combination of rapid interaction with sodium channel and the reported action potential lengthening make amiodarone unique among Class I antiarrhythmic drugs.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
19
|
| pubmed:volume |
112
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
419-22
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:4018143-Action Potentials,
pubmed-meshheading:4018143-Amiodarone,
pubmed-meshheading:4018143-Animals,
pubmed-meshheading:4018143-Benzofurans,
pubmed-meshheading:4018143-Dogs,
pubmed-meshheading:4018143-Guinea Pigs,
pubmed-meshheading:4018143-Heart,
pubmed-meshheading:4018143-Heart Conduction System,
pubmed-meshheading:4018143-Myocardial Contraction,
pubmed-meshheading:4018143-Papillary Muscles,
pubmed-meshheading:4018143-Purkinje Fibers
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Use-dependent effects of amiodarone on Vmax in cardiac Purkinje and ventricular muscle fibers.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|