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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1985-9-11
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pubmed:abstractText |
The kinetics of the epimers of moxalactam (R-MOX, S-MOX) were investigated in patients without infections who were receiving continuous ambulatory peritoneal dialysis after both intravenous and intraperitoneal injections of moxalactam. R-MOX and S-MOX were well absorbed from the peritoneal cavity, with mean systemic availability of 0.71 +/- 0.18 and 0.79 +/- 0.18, respectively. After intravenous MOX, serum clearance was 10.2 +/- 3.4 (R-MOX) and 10.9 +/- 3.2 (S-MOX) ml/hr/kg. Net time-averaged peritoneal dialysis clearance of both epimers was minimal, about 10% of serum clearance. Serum and dialysate MOX concentrations were above the minimum inhibitory concentrations for susceptible bacteria for 24 hours after a 2.0 or 1.0 gm intravenous or intraperitoneal dose. Gastrointestinal side effects occurred after a 2.0 gm dose (both intravenous and intraperitoneal) but not after a 1.0 gm dose. There were no significant differences in the kinetics of R-MOX and S-MOX. A single 1.0 gm ip dose leads to serum and dialysate MOX concentrations above the minimum inhibitory concentration for susceptible pathogens for 24 hours.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9236
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
150-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:4017417-Adult,
pubmed-meshheading:4017417-Biological Availability,
pubmed-meshheading:4017417-Diarrhea,
pubmed-meshheading:4017417-Female,
pubmed-meshheading:4017417-Humans,
pubmed-meshheading:4017417-Infusions, Parenteral,
pubmed-meshheading:4017417-Injections, Intraperitoneal,
pubmed-meshheading:4017417-Injections, Intravenous,
pubmed-meshheading:4017417-Kidney Failure, Chronic,
pubmed-meshheading:4017417-Kinetics,
pubmed-meshheading:4017417-Male,
pubmed-meshheading:4017417-Moxalactam,
pubmed-meshheading:4017417-Peritoneal Dialysis,
pubmed-meshheading:4017417-Peritoneal Dialysis, Continuous Ambulatory,
pubmed-meshheading:4017417-Stereoisomerism
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pubmed:year |
1985
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pubmed:articleTitle |
Moxalactam epimer disposition in patients undergoing continuous ambulatory peritoneal dialysis.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|