| pubmed-article:4016743 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4016743 | lifeskim:mentions | umls-concept:C0012203 | lld:lifeskim |
| pubmed-article:4016743 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:4016743 | lifeskim:mentions | umls-concept:C1866942 | lld:lifeskim |
| pubmed-article:4016743 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:4016743 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:4016743 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:4016743 | pubmed:dateCreated | 1985-8-28 | lld:pubmed |
| pubmed-article:4016743 | pubmed:abstractText | The influence of diethylstilbestrol (DES) on the SCE frequency was studied in various cell systems (V79, HTC, DON, WI-38, human lymphocytes) differing in their ability to metabolize the two promutagens benzo(a)pyrene and cyclophosphamide as well as after incubation with exogenous metabolic systems (S9 mix and peroxidase/H2O2) and in vivo on cells from the bone marrow of the Chinese hamster. DES concentrations from 10(-6) to 10(-4) M were tested. Slight SCE induction was observed only at the highest concentration (10(-4) M) of DES in human lymphocytes treated with DES for the entire culture period of 72 h and in DON cells. No increase of the SCE rate was determined in the other cell lines and in vivo. The combination with S9 mix or peroxidase/H2O2 also had no influence on the SCE frequency. These findings cast doubt on the assumption that DES is metabolized to a DNA-damaging compound subsequently leading to SCE induction. The positive findings in the SCE test are more likely to be products of an indirect and rather unspecific effect. | lld:pubmed |
| pubmed-article:4016743 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4016743 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4016743 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:4016743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4016743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4016743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4016743 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4016743 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4016743 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:4016743 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:4016743 | pubmed:author | pubmed-author:VogelWW | lld:pubmed |
| pubmed-article:4016743 | pubmed:author | pubmed-author:SpeitGG | lld:pubmed |
| pubmed-article:4016743 | pubmed:author | pubmed-author:MehnertKK | lld:pubmed |
| pubmed-article:4016743 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4016743 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:4016743 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4016743 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4016743 | pubmed:pagination | 3626-30 | lld:pubmed |
| pubmed-article:4016743 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
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| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
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| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:meshHeading | pubmed-meshheading:4016743-... | lld:pubmed |
| pubmed-article:4016743 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:4016743 | pubmed:articleTitle | Effect of diethylstilbestrol on the frequencies of sister chromatid exchange in vitro and in vivo. | lld:pubmed |
| pubmed-article:4016743 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4016743 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
