pubmed:abstractText |
The contractile response of small myometrial specimens from the term pregnant human uterus was investigated using a superfusion technique. Adrenaline, noradrenaline and dopamine all had a stimulatory effect on the contractility. It was also demonstrated that this stimulatory effect was alpha-adrenoceptor mediated. If the tissue was pretreated with the prostaglandin synthetase inhibitor indomethacin or the arachidonic acid analogue eicosa-5,8,11,14-tetraenoic acid the effect of catecholamines was significantly reduced. This suggests a specific role of prostaglandins in the mechanism of action of catecholamines on the human myometrium.
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