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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1985-8-21
|
| pubmed:abstractText |
Various dipsogenic stimuli, including peripheral and central administration of angiotensin II, have been shown to be capable of releasing vasopressin from the neurohypophyseal system. Studies were carried out in the rat to investigate whether the septal area, which contains a high concentration of angiotensin-sensitive cells and has neural connections with hypothalamic vasopressin-secreting neurons, mediated the stimulatory effect produced by angiotensin II on vasopressin release. Rats with electrolytic lesions in the region of the septal area had increased daily water consumption and urine output when these lesions included the medioventral or lateral nuclei of the septal forebrain, but not when the lesion involved the subfornical organ. No difference was observed in drinking responses following water deprivation or intracerebroventricular injection of angiotensin II in all experimental groups. In addition, the impaired ability to maintain water homeostasis (polyuro-polydipsic syndrome) of septal-lesioned rats was associated septal-lesioned rats was associated with decreased levels of circulating radioimmunoassayable vasopressin. Furthermore, the vasopressin release which occurred in response to intracerebroventricular angiotensin II in normal controls, sham-lesioned and subfornical organ-lesioned rats was significantly attenuated in rats with electrolytic lesion of the medioventral or lateral septal area. Since cells in the lateral septal area are excited by iontophoretic application of angiotensin II, the present data might be consistent with the hypothesis that the stimulatory effect produced by central administration of angiotensin II on vasopressin release rests upon the integrity of the lateral septal area.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0306-4522
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
61-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:4010935-Angiotensin II,
pubmed-meshheading:4010935-Animals,
pubmed-meshheading:4010935-Brain Mapping,
pubmed-meshheading:4010935-Diuresis,
pubmed-meshheading:4010935-Drinking Behavior,
pubmed-meshheading:4010935-Hypothalamo-Hypophyseal System,
pubmed-meshheading:4010935-Male,
pubmed-meshheading:4010935-Neurosecretory Systems,
pubmed-meshheading:4010935-Rats,
pubmed-meshheading:4010935-Rats, Inbred Strains,
pubmed-meshheading:4010935-Septum Pellucidum,
pubmed-meshheading:4010935-Subfornical Organ,
pubmed-meshheading:4010935-Thirst,
pubmed-meshheading:4010935-Vasopressins
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Thirst and vasopressin secretion following central administration of angiotensin II in rats with lesions of the septal area and subfornical organ.
|
| pubmed:publicationType |
Journal Article
|