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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-7-30
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pubmed:databankReference |
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pubmed:abstractText |
The nucleotide sequence of the envelope (env) gene and the long terminal repeat (LTR) of an infectious clone of Rauscher mink cell focus-inducing (R-MCF) virus has been determined and compared with the published env gene and LTR sequences of Friend (F)- and Moloney (M)-MCF viruses. The sequence shows that R-MCF virus, like other MCF viruses, is a recombinant virus. Its env gene contains sequences which were acquired from an env gene in the mouse genome and which confer on the MCF virus its dualtropic host range. Unlike F-MCF and M-MCF viruses, R-MCF virus will not replicate in NIH 3T3 cells. The deduced amino acid sequence for the gp70 of R-MCF differs from that of F- and M-MCF viruses by 15 amino acids between residues 49 and 138 of gp70. These differences in amino acid sequences may be responsible for the inability of R-MCF virus to replicate in NIH 3T3 cells. The host range of two hybrid viruses constructed in vitro is consistent with this hypothesis. R-MCF virus and Friend murine leukemia virus (F-MLV) show 98% identity in their env gene 3' from the acquired env sequences. This contrasts with 82% identity between the env gene of R-MCF virus and M-MLV. The LTR of R-MCF shows 98% identity with the LTR of F-MCF as compared to 88% identity with the LTR of M-MCF. This striking similarity between the sequences of R-MCF, F-MCF, and F-MLV is surprising since the Rauscher virus and the Friend virus are thought to have originated independently. The high degree of similarity suggests that Rauscher and Friend viruses have a common origin. In contrast to M-MLV, which induces predominantly a lymphoid disease, R- and F-MCF viruses induce an erythroproliferative disease in NIH Swiss mice. A hybrid R-MCF virus with a genome derived primarily from R-MCF virus and a 3' end including the U3 region derived from M-MLV induces a lymphoid disease instead of an erythroid disease. This result indicates that it is the U3 region which determines the tissue specificity of the MCF virus-induced disease. It is suggested that the putative viral enhancers in the U3 region play two roles in the process of leukemogenesis: in the Friend and Rauscher disease, the viral enhancers act by increasing the transcription of the MCF env gene; in the thymic lymphoma, the enhancers activate mainly the expression of cellular genes.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-130004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-13416470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-14490596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-187721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-206001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-219598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-4291934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-4404347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6088793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6088801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6090701,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6092670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6093121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6169994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6173134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6202886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6245244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6267802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6268733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6292529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6296423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6308605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6308622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6308644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6312107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6321768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6326104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6327047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6327049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6328011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6329737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6681736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6928730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6952652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-6955527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-7143566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4009793-725603
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
184-92
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4009793-Amino Acid Sequence,
pubmed-meshheading:4009793-Animals,
pubmed-meshheading:4009793-Base Sequence,
pubmed-meshheading:4009793-Cloning, Molecular,
pubmed-meshheading:4009793-DNA, Recombinant,
pubmed-meshheading:4009793-DNA, Viral,
pubmed-meshheading:4009793-Defective Viruses,
pubmed-meshheading:4009793-Friend murine leukemia virus,
pubmed-meshheading:4009793-Genes, Viral,
pubmed-meshheading:4009793-Lymphoma,
pubmed-meshheading:4009793-Mice,
pubmed-meshheading:4009793-Moloney murine leukemia virus,
pubmed-meshheading:4009793-Rauscher Virus,
pubmed-meshheading:4009793-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:4009793-Retroviridae,
pubmed-meshheading:4009793-Species Specificity,
pubmed-meshheading:4009793-Viral Envelope Proteins
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pubmed:year |
1985
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pubmed:articleTitle |
Envelope gene and long terminal repeat determine the different biological properties of Rauscher, Friend, and Moloney mink cell focus-inducing viruses.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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