Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-8-20
pubmed:abstractText
The purpose of this investigation was to determine the effects of subtotal surgical nephrectomy (three-quarters removal of renal mass) on the renal handling of gentamicin in the dog. Three and one-half months after surgery, dogs were anesthetized and steady-state clearances of gentamicin, creatinine, inulin and p-aminohippurate were determined. Subtotal nephrectomy proportionately decreased creatinine, inulin and p-aminohippurate clearances, but resulted in a significantly (P less than .05) decreased fractional excretion of gentamicin (0.97 +/- 0.24) (mean +/- S.D.) compared to intact dogs (1.22 +/- 0.08). Gentamicin serum protein binding by equilibrium dialysis was approximately 15% in both groups. In vitro canine cortical tissue slices accumulated drug as the slice/medium ratio was greater than one (1.77 +/- 0.47). This study indicates that the renal handling of gentamicin is altered in this disease model. This decreased fractional excretion of gentamicin implies that the quantity of drug excreted by the diseased kidney cannot be precisely predicted on the basis of glomerular filtration rate alone when drug dosage regimens are designed for patients with renal disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
234
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
90-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Decreased fractional renal excretion of gentamicin in subtotal nephrectomized dogs.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.