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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1985-8-20
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pubmed:abstractText |
A method for the measurement of 3H-monoamine [noradrenaline (NA) and 5-hydroxytryptamine (5-HT)] uptake into intact brain following intracerebroventricular injection is described. Most of the accumulated monoamine was associated with nerve terminals (synaptosomes). Radioactivity in the synaptosomal fraction was retained by 0.45-micron filters and was osmotically sensitive, features indicative of accumulation within particles rather than binding to membranes. [3H]5-HT associated with synaptosomes was reduced in animals pretreated with the neurotoxin 5,7-dihydroxytryptamine, in parallel with a reduction in endogenous 5-HT levels. Oral administration of tricyclic antidepressants including clomipramine, desipramine, and imipramine inhibited the synaptosomal accumulation of 3H-monoamines. Overall, the features of the accumulation of 3H-monoamines, after intracerebroventricular administration, displayed many of the characteristics expected of a physiological monoamine reuptake system.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-3042
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
456-60
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:4009169-5,7-Dihydroxytryptamine,
pubmed-meshheading:4009169-Animals,
pubmed-meshheading:4009169-Brain,
pubmed-meshheading:4009169-Brain Chemistry,
pubmed-meshheading:4009169-Imipramine,
pubmed-meshheading:4009169-Injections, Intraventricular,
pubmed-meshheading:4009169-Male,
pubmed-meshheading:4009169-Norepinephrine,
pubmed-meshheading:4009169-Rats,
pubmed-meshheading:4009169-Rats, Inbred Strains,
pubmed-meshheading:4009169-Serotonin,
pubmed-meshheading:4009169-Subcellular Fractions
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pubmed:year |
1985
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pubmed:articleTitle |
Assessment of noradrenaline and 5-hydroxytryptamine uptake in intact rat brain.
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pubmed:publicationType |
Journal Article
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