Linked Life Data

4008974

Source:http://linkedlifedata.com/resource/pubmed/id/4008974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-8-12
pubmed:abstractText
The role of Langerhans cell granules (LCG) in adsorptive endocytosis was studied by using concanavalin A (Con A) and heterologous anti-epidermal cell serum (AES) as ligands. Isolated epidermal cells were obtained by trypsinization of guinea pig skin fragments and exposed to ferritin-conjugated Con A or AES followed by ferritin-conjugated second antibody at 37 degrees C for various times up to 30 min. Langerhans cells among the treated epidermal cells were observed by electron microscopy. Shortly after the incubation, a few LCG in the cell periphery were filled with ferritin particles in the bulb portion. After prolonged incubation, ferritin-containing LCG increased in number and seemed to move to the juxtanuclear area. The granules were derived from plasma membrane invaginations that collected ferritin particles in a saclike extension at the end. Some of these invaginations were apparently of coated pit origin. The contents in the bulb of LCG seemed to be delivered finally to intracellular degradation compartments. Our findings clearly demonstrate that LCG are an adsorptive endocytic organelle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The Langerhans cell granule is an adsorptive endocytic organelle.
pubmed:publicationType
Journal Article