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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1985-7-29
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pubmed:abstractText |
The natural history of stinging insect allergy and its modification by venom immunotherapy was investigated by follow-up observations of patients with histories of venom anaphylaxis and detectable venom-specific IgE. The patients were divided into three categories: (1) receiving venom immunotherapy, (2) declined venom immunotherapy, and (3) terminated venom immunotherapy. One hundred twenty-seven patients were evaluated after 6 mo to 9 yr of venom immunotherapy. Most received top venom doses of 50 micrograms of yellow jacket and/or honeybee venoms every 4 wk. There were 87 restings in 48 patients resulting in two systemic reactions, only one of which could be considered a treatment failure (1%). Fifty-six patients never received venom immunotherapy. In this group there were 40 restings in 28 patients with 14 systemic reactions (35%). In 88 patients who stopped venom immunotherapy, 61 restings in 41 patients led to 11 systemic reactions (17%). Patients with cardiovascular/or respiratory symptoms with initial sting anaphylaxis were at risk for subsequent reactions. With one exception, patients with hives and edema only as the initial reaction either had a similar or no reaction when they were restung. These results confirm the efficacy of venom immunotherapy but also suggest that there are factors other than the presence of venom-specific IgE modulating the occurrence of clinical anaphylaxis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0091-6749
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
735-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:4008803-Adolescent,
pubmed-meshheading:4008803-Adult,
pubmed-meshheading:4008803-Aged,
pubmed-meshheading:4008803-Anaphylaxis,
pubmed-meshheading:4008803-Bee Venoms,
pubmed-meshheading:4008803-Child,
pubmed-meshheading:4008803-Child, Preschool,
pubmed-meshheading:4008803-Female,
pubmed-meshheading:4008803-Follow-Up Studies,
pubmed-meshheading:4008803-Humans,
pubmed-meshheading:4008803-Immunotherapy,
pubmed-meshheading:4008803-Insect Bites and Stings,
pubmed-meshheading:4008803-Male,
pubmed-meshheading:4008803-Middle Aged,
pubmed-meshheading:4008803-Time Factors,
pubmed-meshheading:4008803-Wasp Venoms
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pubmed:year |
1985
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pubmed:articleTitle |
Stinging insect allergy: natural history and modification with venom immunotherapy.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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