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rdf:type |
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lifeskim:mentions |
umls-concept:C0009498,
umls-concept:C0019652,
umls-concept:C0220781,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0443199,
umls-concept:C0596997,
umls-concept:C0598312,
umls-concept:C1705920,
umls-concept:C1883254,
umls-concept:C1948027
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pubmed:issue |
1
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pubmed:dateCreated |
1985-8-5
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pubmed:abstractText |
Proportions of the four major chicken H-1 histones (referred to as H-1's a-d) change during in vitro skeletal myogenesis. As myoblasts fuse and differentiate into myotubes, the relative amount of H-1c increases dramatically. The change occurs primarily because synthesis of the H-1 species is coupled to DNA synthesis to different extents. H-1c synthesis is least tightly coupled to DNA replication in precursor myoblasts and in differentiated myotubes. Thus H-1c synthesis predominates after dividing myoblasts fuse into postmitotic myotubes. This results in the replacement of pre-existing H-1 and therefore increases the relative amount of H-1c. Differences in the stability of the H-1's are also involved in changing H-1 proportions. The results show that changes in H-1 proportions during myogenesis are a consequence of withdrawal from the cell cycle. The data provides a general mechanistic explanation of how tissue-specific H-1 proportions are established.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-1064861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-1175627,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-13563465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-14332648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-209584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-266711,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-387806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-4329509,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-5090040,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-5840387,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-6793234,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-6848501,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-7066298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-7126528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-7159589,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-7199388,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-789809,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/4008526-967672
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9525
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
167-74
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1985
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pubmed:articleTitle |
Changes in the H-1 histone complement during myogenesis. I. Establishment by differential coupling of H-1 species synthesis to DNA replication.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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