Linked Life Data

4008418

Source:http://linkedlifedata.com/resource/pubmed/id/4008418

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-8-21
pubmed:abstractText
To obtain a detailed description of the dependence of pulmonary blood flow on changes in lung volume, we perfused isolated rabbit lungs with homologous blood at 37 degrees C while controlling vascular pressures during lung deflation. We set pulmonary arterial pressure (Ppa) and pulmonary venous pressure (Ppv) to constant values relative to alveolar pressure (Palv) to keep the effective driving pressure for flow constant during lung deflation from total lung capacity (TLC) to 25% TLC. The shapes of the flow vs. lung volume curves were dependent on the levels of Ppa-Palv and Ppv-Palv at which they were obtained. When Ppv greater than Palv throughout the lung (zone 3 conditions), flow increased as the lungs were deflated from TLC, independent of the level of Ppa-Palv. When Ppv less than Palv (zone 2 conditions) and Ppa-Palv was moderately high, flow increased as the lungs were deflated from 100 to approximately 50% TLC, then decreased at lower lung volumes. When Ppa - Palv was less than 10 cmH2O in zone 2 conditions, flow decreased monotonically during deflation from TLC. We concluded that the dependence of blood flow on lung volume is complex, which may be a reflection of the nonlinear pressure-diameter properties of pulmonary vessels.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
8750-7587
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2004-10
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Pulmonary blood flow vs. gas volume at various perfusion pressures in rabbit lung.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't