Linked Life Data

4007286

Source:http://linkedlifedata.com/resource/pubmed/id/4007286

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1985-8-2
pubmed:abstractText
We have studied the structure of the insulin receptor from a human cultured monocyte cell line, U-937. The receptor is composed of alpha and beta subunits as seen in other insulin receptors, but these subunits are of greater apparent molecular weight (alpha 150,000 and beta 102,000) than in typical insulin receptors. Despite this, the U-937 insulin receptor appears to function normally. The alpha subunit binds insulin and the beta subunit is phosphorylated in response to insulin stimulation. Both subunits are expressed in the plasma membrane. Insulin binding isotherms are similar to those seen in IM-9 lymphocytes. Thus, the insulin receptor from U-937 monocytes appears functionally normal despite alterations in molecular weight of the subunits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
686-90
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
An alteration in apparent molecular weight of the insulin receptor from the human monocyte cell line U-937.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't