Linked Life Data

4005147

Source:http://linkedlifedata.com/resource/pubmed/id/4005147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-8-2
pubmed:abstractText
The effect of macrophage inactivation on lysolecithin-induced demyelination was studied. Adult rats were pretreated with a single intraperitoneal dose of 200 mg silica quartz dust, which selectively blocks the activity of circulating monocytes. Surgery was performed the following day and 2 microliters of 1% lysolecithin were injected intraspinally. The animals were perfused with aldehydes at 8 to 60 days postoperatively. Tissues were examined by optical and electron microscopy. The injection of lysolecithin produced a localized demyelinating lesion. Myelin debris in controls was phagocytosed by invading macrophages. Axons within the lesion appeared denuded. At later stages remyelination occurred. When animals were pretreated with silica, the macrophage response was remarkably reduced. The clearance of collapsed myelin was delayed. Accumulation of fluid within the sheaths resulted in tissue oedema and persistent spongiform changes. At 28 and 60 days postoperatively, increased fibrillary astrogliosis was observed but did not appear to interfere with remyelination. The findings of this study suggest that (a) active participation of macrophages is essential for the attainment of demyelination in the lysolecithin model and (b) treatment with silica prevents complete demyelination but has no apparent effect on remyelination.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1021
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-301
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Effect of macrophage inactivation on the neuropathology of lysolecithin-induced demyelination.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't