|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0011685,
umls-concept:C0025681,
umls-concept:C0031923,
umls-concept:C0034121,
umls-concept:C0041479,
umls-concept:C0055708,
umls-concept:C0205191,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707455,
umls-concept:C1708335,
umls-concept:C2911692
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1985-7-31
|
|
pubmed:abstractText |
Twenty-nine healthy volunteers participated in an experiment lasting for 8 weeks: Phase I (2 weeks)--pre-treatment control period; Phase II (4 weeks)--medication with either ciclazindol hydrochloride (50 mg twice daily), or desipramine hydrochloride (50 mg twice daily) or lactose placebo (twice daily) administered in a single-blind fashion; Phase II (2 weeks)--recovery. Experimental sessions took place twice weekly for the photographic assessment of resting pupil diameter, and for the assessment of one of the following pupillary responses: mydriatic response to methoxamine, mydriatic response to tyramine, miotic response to pilocarpine. Resting pupil diameter increased during medication with either ciclazindol or desipramine. Methoxamine-evoked mydriasis and tyramine-evoked mydriasis were antagonized by both ciclazindol and desipramine. Pilocarpine-evoked miosis was potentiated by both ciclazindol and desipramine. The steady-state plasma levels (mean +/- s.e. mean) of the antidepressants were: ciclazindol: 5.90 +/- 0.74 microM; desipramine: 0.60 +/- 0.17 microM. The antagonism of methoxamine-evoked mydriasis is likely to reflect the blockade of postsynaptic alpha 1-adrenoceptors in the iris by the antidepressants, whereas the antagonism of tyramine-evoked mydriasis may reflect both the blockade of uptake of tyramine into presynaptic adrenergic terminals and the blockade of postsynaptic alpha-adrenoceptors. There is no immediate explanation for the potentiation of pilocarpine-evoked miosis by the two antidepressants.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-1233998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-14603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-4155974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-507990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-508534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-5781738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-588839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-6163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-6265223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-6267618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-6352281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-7074302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-7438688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-7470769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-843425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-901726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-901738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4005103-96461
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0306-5251
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
639-47
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:4005103-Adolescent,
pubmed-meshheading:4005103-Adult,
pubmed-meshheading:4005103-Antidepressive Agents, Tricyclic,
pubmed-meshheading:4005103-Desipramine,
pubmed-meshheading:4005103-Female,
pubmed-meshheading:4005103-Humans,
pubmed-meshheading:4005103-Indoles,
pubmed-meshheading:4005103-Male,
pubmed-meshheading:4005103-Methoxamine,
pubmed-meshheading:4005103-Pilocarpine,
pubmed-meshheading:4005103-Pupil,
pubmed-meshheading:4005103-Tyramine
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Comparison of the effects of chronic administration of ciclazindol and desipramine on pupillary responses to tyramine, methoxamine and pilocarpine in healthy volunteers.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|
