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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-7-11
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pubmed:abstractText |
Total kininogen in plasma of Freund's adjuvant treated rats increased 20-fold 7 days following the injection. Analysis of the kininogens demonstrated that increases in T-kininogen was the major reason for the rise in kininogen. High molecular weight and low molecular weight kininogens showed little or no change. The increase in T-kininogen paralleled the inflammatory condition. Anti-inflammatory agents which reduced paw swelling also reduced plasma T-kininogen levels. Unidentified peaks on HPLC of kinin following plasma treatment by trypsin were shown to be oligopeptides containing T-kinin (Ile-serbradykinin). The relationship of T-kininogen to the inflammatory response is discussed.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
280-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:4004880-Animals,
pubmed-meshheading:4004880-Arthritis,
pubmed-meshheading:4004880-Arthritis, Experimental,
pubmed-meshheading:4004880-Chromatography, High Pressure Liquid,
pubmed-meshheading:4004880-Dexamethasone,
pubmed-meshheading:4004880-Indomethacin,
pubmed-meshheading:4004880-Kininogens,
pubmed-meshheading:4004880-Kinins,
pubmed-meshheading:4004880-Male,
pubmed-meshheading:4004880-Molecular Weight,
pubmed-meshheading:4004880-Rats,
pubmed-meshheading:4004880-Rats, Inbred Strains,
pubmed-meshheading:4004880-Trypsin
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pubmed:year |
1985
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pubmed:articleTitle |
T-kininogen--the major plasma kininogen in rat adjuvant arthritis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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