Linked Life Data

4003773

Source:http://linkedlifedata.com/resource/pubmed/id/4003773

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-7-2
pubmed:abstractText
This study was designed to investigate sex differences in halothane metabolism and hepatotoxicity in the hypoxic rat model. Phenobarbital-induced male and female rats were anesthetized with 1% halothane in 14% oxygen for two hours. Female rats were found to metabolize halothane by the oxidative pathway to a similar extent as males, but the extent of metabolism by the reductive pathway was less in females. All male rats exposed under these conditions developed confluent centrilobular hepatic necrosis. Females were less susceptible than males to the hepatotoxic effect of halothane, with responses ranging from no hepatic injury to confluent centrilobular necrosis limited to within a few cells of the central veins. This lesser susceptibility was not, however, solely due to the lesser extent of reductive metabolism in females, as lowering the inspired oxygen concentration to 12% increased the extent of reductive metabolism but did not increase the severity of the hepatic injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0003-2999
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
563-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Sex differences in halothane metabolism and hepatotoxicity in a rat model.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't