Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1985-7-25
|
| pubmed:abstractText |
Pharmacokinetics and clinical effects of muzolimine were investigated in 6 hypertensive patients with incipient renal insufficiency. Muzolimine plasma levels were determined after the first dose and after 8 weeks of treatment with muzolimine (20 mg o.d.). The area under the curve of muzolimine plasma levels was greater after 8 weeks than after the first dose. Also, peak plasma concentrations were higher after 8 weeks; however, muzolimine half-lives in the beta-phase were unchanged. Blood pressure and body weight decreased with time. Muzolimine was well tolerated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-5860
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
74 Suppl 2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
77-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:4002808-Adult,
pubmed-meshheading:4002808-Blood Pressure,
pubmed-meshheading:4002808-Creatinine,
pubmed-meshheading:4002808-Humans,
pubmed-meshheading:4002808-Hypertension,
pubmed-meshheading:4002808-Kidney Diseases,
pubmed-meshheading:4002808-Kinetics,
pubmed-meshheading:4002808-Middle Aged,
pubmed-meshheading:4002808-Muzolimine,
pubmed-meshheading:4002808-Pyrazoles,
pubmed-meshheading:4002808-Time Factors
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Pharmacokinetics of muzolimine after acute and chronic dosing in hypertensive patients with mild renal insufficiency.
|
| pubmed:publicationType |
Journal Article
|