Linked Life Data

4002792

Source:http://linkedlifedata.com/resource/pubmed/id/4002792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1985-7-25
pubmed:abstractText
The metabolism of muzolimine, 3-amino-1-(3,4-dichloro-alpha-methyl-benzyl)-2-pyrazoline-5-one has been studied both in vivo and in vitro in various animal species. Using unlabelled muzolimine the major urinary metabolite in all species studied has been shown by chromatography and mass-spectrometry to have properties identical to synthetic N'-(1-aminoethylidene)-3,4-dichloro-acetophenone hydrazone. In addition, 3,4-dichloroacetophenone, 3,4-dichloromandelic and 3,4-dichlorobenzoic acids have been detected and quantified using GLC techniques. In vitro experiments using hepatic microsomal preparations from various species show that cleavage across the C-N1 bond occurs yielding 3,4-dichloroacetophenone and 3-amino-2-pyrazoline-5-one. The hydrazone was the major metabolite produced by these systems. Moreover, this compound also appears as the major metabolite in faecal extracts. Reverse-Phase High-Performance Liquid Chromatographic techniques have been employed for analysis of in vitro metabolism of muzolimine and confirmed the formation of the above metabolites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
74 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
152-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The metabolism of muzolimine.
pubmed:publicationType
Journal Article, In Vitro