Linked Life Data

4002240

Source:http://linkedlifedata.com/resource/pubmed/id/4002240

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-7-11
pubmed:abstractText
Trichloroethylene (TCE) produced bronchiolar damage when administered to mice. Administration of 2000 mg/kg caused injury in Clara cells of the bronchiolar epithelium, which was observed at 24 h following TCE treatment; increase of the dosage to 2500 mg/kg induced additionally, alterations in alveolar Type II cells of the parenchyma. Specifically, lamellar bodies were reduced in number and microvilli displayed distorted protrusions. The increase in severity of cellular injury with higher dosages of TCE coincided with increased accumulation of pulmonary calcium and lengthened anesthesia recovery times following TCE-induced anesthesia. Time-course studies conducted with 2000 mg/kg demonstrated rapid and marked reduction in pulmonary microsomal cytochrome P-450 content and aryl hydrocarbon hydroxylase activity. Significant decreases were observed as early as 1 h, and the levels were still depressed at 24 h following TCE treatment. Hepatic necrosis was relatively mild at the dosages of TCE examined. These results demonstrate that TCE is pneumotoxic and affects Clara and alveolar Type II cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0300-483X
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-60
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Lung injury induced by trichloroethylene.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't