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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4-6
|
pubmed:dateCreated |
1985-7-9
|
pubmed:abstractText |
Cholecystokinin octapeptide (CCK-8), given intracerebroventricularly (icv) or intrathecally (ith) at the dose range of 0.25-4.0 ng, dose-dependently antagonised the effect of morphine analgesia and electroacupuncture analgesia (EAA) in the rat. That CCK-8 antiserum was capable of reversing the tolerance to EAA and changing the non-responders of EAA into responders suggest CCK-8 to be the endogenous anti-opioid substrate and that blocking the effect of CCK-8 may prove to be a powerful way of augmenting the effect of morphine analgesia and EA analgesia.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0143-4179
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
399-402
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:4000412-Acupuncture Therapy,
pubmed-meshheading:4000412-Animals,
pubmed-meshheading:4000412-Brain,
pubmed-meshheading:4000412-Injections, Intraventricular,
pubmed-meshheading:4000412-Morphine,
pubmed-meshheading:4000412-Pain,
pubmed-meshheading:4000412-Rats,
pubmed-meshheading:4000412-Sincalide
|
pubmed:year |
1985
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pubmed:articleTitle |
Is cholecystokinin octapeptide (CCK-8) a candidate for endogenous anti-opioid substrates?
|
pubmed:publicationType |
Journal Article,
Comparative Study
|