Linked Life Data

3997599

Source:http://linkedlifedata.com/resource/pubmed/id/3997599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1985-7-9
pubmed:abstractText
The kinetics of cellular inactivation by fractionated irradiation in Lewis lung carcinoma was studied in the dose range of 2.3 to 6.5 Gy per fraction. Regimens of one and two fractions per day for 10 days were compared. The number of clonogenic tumor cells was determined using an in vitro soft-agar colony assay. Under the experimental conditions used, the fraction of tumor cells inactivated per day was only dependent on the total dose per day, i.e., the cellular response was the same whether the daily dose was given in one or two fractions. Thus, the two fraction per day regimen was more effective than expected from calculations based on acute in vivo radiation dose-survival curves. This result could be explained if the clonogenic tumor cells were less hypoxic during the two fractions per day regimen than the one fraction per day schedule.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0360-3016
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1171-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Kinetics of cellular inactivation by fractionated and hyperfractionated irradiation in Lewis lung carcinoma.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't