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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1985-7-25
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pubmed:abstractText |
The metabolism of all-trans-[15-14C]retinoic acid in vitamin A-adequate or vitamin A-deficient rats fed retinoic acid was studied following intratesticular injection. Analysis of testicular metabolites by HPLC at 1, 6, and 24 h demonstrated that the retinoic acid was isomerized to 13-cis-retinoic acid and metabolized to polar metabolites in both groups of rats at all time periods. However, polar metabolites predominated in the testes of the vitamin A-deficient rats. At 24 h the total radioactivity remaining in the testis was much lower in the testes of vitamin A-deficient rats than in normal animals suggesting a faster rate of metabolism of all-trans-retinoic acid in these rats.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-9831
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-23
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3997394-Animals,
pubmed-meshheading:3997394-Chromatography, High Pressure Liquid,
pubmed-meshheading:3997394-Kinetics,
pubmed-meshheading:3997394-Male,
pubmed-meshheading:3997394-Rats,
pubmed-meshheading:3997394-Stereoisomerism,
pubmed-meshheading:3997394-Testis,
pubmed-meshheading:3997394-Tretinoin,
pubmed-meshheading:3997394-Vitamin A Deficiency
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pubmed:year |
1985
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pubmed:articleTitle |
Metabolism of all-trans-retinoic acid in rat testis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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