Linked Life Data

3995318

Source:http://linkedlifedata.com/resource/pubmed/id/3995318

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-7-24
pubmed:abstractText
Besides the nigro-collicular pathway, the nigro-thalamic projection to the ventromedial thalamic nucleus represents another efferent system of the basal ganglia through which striatum can influence motor centers. Since the striato-nigrothalamic circuit is composed of two successive GABAergic inhibitory links and the SNR is tonically active, we tested that by inhibiting nigrothalamic cells, the striatum may exert a facilitatory influence on VM-thalamocortical cells. We show that a transitory block of SNR (substantia nigra pars reticulata) firing (induced by either intranigral application of GABA or by stimulating the inhibitory striato-nigral pathway), causes a perfectly time-locked increase of activity in a large number of VM cells projecting to motor cortex. Moreover, the striatally evoked excitation of VM-thalamocortical cells requires the functional integrity of the GABAergic striato-nigral link. We conclude that the double inhibitory striato-nigrothalamic pathway acts on VM-thalamocortical cells through a disinhibitory mechanism. The functional implication of such a mechanism is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
334
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
227-33
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Disinhibition as a basic process in the expression of striatal functions. II. The striato-nigral influence on thalamocortical cells of the ventromedial thalamic nucleus.
pubmed:publicationType
Journal Article