Linked Life Data

3995317

Source:http://linkedlifedata.com/resource/pubmed/id/3995317

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1985-7-24
pubmed:abstractText
The diuretic, amiloride, is a potent yet reversible inhibitor of passive sodium transport in many epithelia. It has been shown to inhibit sodium transport in dorsal lingual epithelia and to inhibit both psychophysical and neural measures of salt taste. The present results demonstrate that amiloride's action as an inhibitor of integrated whole chorda tympani nerve recordings in the rat is specific for Li and Na salts, displaying little inhibition of neural responses evoked by KCl and RbCl. Amiloride reduces both the phasic and tonic portion of the nerve recording equally. When amiloride inactivates the tonic portion of the nerve response to 250 mM NaCl, only a portion of the response is affected. Complete inactivation does not occur even at high amiloride concentrations. With amiloride flowing constantly over the tongue at 1 microM, 10 microM, or 50 microM a reciprocal plot of stimulus NaCl concentration versus response is non-linear. This result suggests that the inhibition of the NaCl-induced response has both competitive and non-competitive properties. These results support the hypothesis that salt taste is mediated in part by amiloride sensitive Na-channels located in taste receptor cell plasma membranes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
334
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
207-14
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Inhibition by amiloride of chorda tympani responses evoked by monovalent salts.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't